Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists

Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists

Compounds featuring a 1,2,4-oxadiazole core have been recently identified as a new chemotype of farnesoid X receptor (FXR) antagonists. With the aim to expand this class of compounds and to understand the building blocks necessary to maintain the antagonistic activity, we describe herein the synthes...

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Bibliographic Details
Main Authors: Claudia Finamore, Carmen Festa, Bianca Fiorillo, Francesco Saverio Di Leva, Rosalinda Roselli, Silvia Marchianò, Michele Biagioli, Lucio Spinelli, Stefano Fiorucci, Vittorio Limongelli, Angela Zampella, Simona De Marino
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
farnesoid X receptor antagonist
pregnane X receptor agonist
1,2,4-oxadiazole
inflammatory disorders
Online Access:https://www.mdpi.com/1420-3049/28/6/2840

Internet

https://www.mdpi.com/1420-3049/28/6/2840

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