Principles and functions of condensate modifying drugs

Biomolecular condensates are compartmentalized communities of biomolecules, which unlike traditional organelles, are not enclosed by membranes. Condensates play roles in diverse cellular processes, are dysfunctional in many disease states, and are often enriched in classically “undruggable” targets....

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Bibliographic Details
Main Authors: Avinash Patel, Diana Mitrea, Vigneshwaran Namasivayam, Mark A. Murcko, Michael Wagner, Isaac A. Klein
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Molecular Biosciences
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Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1007744/full