Anti‐PD‐1/Her2 Bispecific Antibody IBI315 Enhances the Treatment Effect of Her2‐Positive Gastric Cancer through Gasdermin B‐Cleavage Induced Pyroptosis

Anti‐PD‐1/Her2 Bispecific Antibody IBI315 Enhances the Treatment Effect of Her2‐Positive Gastric Cancer through Gasdermin B‐Cleavage Induced Pyroptosis

Abstract The majority of patients with human epidermal growth factor receptor 2 (Her2)‐positive gastric cancer develop refractory to Her2‐targeted therapy, where upregulation of immune checkpoints plays an essential role. Herein, a recombinant fully human IgG1 bispecific antibody IBI315 targeting bo...

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Bibliographic Details
Main Authors: Wu Lin, Yingzi Zhang, Yan Yang, Ben Lin, Mengjia Zhu, Jinling Xu, YiRan Chen, Weiwei Wu, Bingliang Chen, Xiangliu Chen, Jin Liu, Haohao Wang, Fei Teng, Xiongfei Yu, Haiyong Wang, Jun Lu, Quan Zhou, Lisong Teng
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Advanced Science
Subjects:
bispecific antibodies
GSDMB
Her2
immunotherapy
pyroptosis
Online Access:https://doi.org/10.1002/advs.202303908

Internet

https://doi.org/10.1002/advs.202303908

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