Neurotoxic Effect of Doxorubicin Treatment on Cardiac Sympathetic Neurons

Neurotoxic Effect of Doxorubicin Treatment on Cardiac Sympathetic Neurons

Doxorubicin (DOXO) remains amongst the most commonly used anti-cancer agents for the treatment of solid tumors, lymphomas, and leukemias. However, its clinical use is hampered by cardiotoxicity, characterized by heart failure and arrhythmias, which may require chemotherapy interruption, with devasta...

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Bibliographic Details
Main Authors: Nicola Moro, Lolita Dokshokova, Induja Perumal Vanaja, Valentina Prando, Sophie Julie A Cnudde, Anna Di Bona, Riccardo Bariani, Leonardo Schirone, Barbara Bauce, Annalisa Angelini, Sebastiano Sciarretta, Alessandra Ghigo, Marco Mongillo, Tania Zaglia
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
Doxorubicin
cardiotoxicity
sympathetic neurons
cardiac innervation
nerve growth factor
Online Access:https://www.mdpi.com/1422-0067/23/19/11098

Internet

https://www.mdpi.com/1422-0067/23/19/11098

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