Environmental Enrichment and Metformin Improve Metabolic Functions, Hippocampal Neuron Survival, and Hippocampal-Dependent Memory in High-Fat/High-Sucrose Diet-Induced Type 2 Diabetic Rats

Environmental Enrichment and Metformin Improve Metabolic Functions, Hippocampal Neuron Survival, and Hippocampal-Dependent Memory in High-Fat/High-Sucrose Diet-Induced Type 2 Diabetic Rats

<b>Background</b>: The Western-style diet-induced type 2 diabetes mellitus (T2D) may eventually trigger neurodegeneration and memory impairment. Thus, it is essential to identify effective therapeutic strategies to overcome T2D complications. This study aimed to investigate the effects o...

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Bibliographic Details
Main Authors: Teh Rasyidah Ismail, Christina Gertrude Yap, Rakesh Naidu, Narendra Pamidi
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biology
Subjects:
type 2 diabetes
memory impairment
environmental enrichment
metformin
hippocampus
BDNF-TrkB signaling pathways
Online Access:https://www.mdpi.com/2079-7737/12/3/480

Internet

https://www.mdpi.com/2079-7737/12/3/480

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