Inherited mitochondrial dysfunction triggered by OPA1 mutation impacts the sensory innervation fibre identity, functionality and regenerative potential in the cornea

Inherited mitochondrial dysfunction triggered by OPA1 mutation impacts the sensory innervation fibre identity, functionality and regenerative potential in the cornea

Abstract Mitochondrial dysfunctions are detrimental to organ metabolism. The cornea, transparent outmost layer of the eye, is prone to environmental aggressions, such as UV light, and therefore dependent on adequate mitochondrial function. While several reports have linked corneal defects to mitocho...

Full description

Bibliographic Details
Main Authors: Léna Meneux, Nadège Feret, Sarah Pernot, Mélissa Girard, Solange Sarkis, Alicia Caballero Megido, Melanie Quiles, Agnès Müller, Laura Fichter, Jerome Vialaret, Christophe Hirtz, Cecile Delettre, Frederic Michon
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Scientific Reports
Subjects:
Mitochondria
Cornea
OPA1
Innervation
Epithelium
Tear film
Online Access:https://doi.org/10.1038/s41598-024-68994-4

Internet

https://doi.org/10.1038/s41598-024-68994-4

Similar Items