Pharmacological rescue of mitochondrial and neuronal defects in SPG7 hereditary spastic paraplegia patient neurons using high throughput assays

Pharmacological rescue of mitochondrial and neuronal defects in SPG7 hereditary spastic paraplegia patient neurons using high throughput assays

SPG7 is the most common form of autosomal recessive hereditary spastic paraplegia (HSP). There is a lack of HSP-SPG7 human neuronal models to understand the disease mechanism and identify new drug treatments. We generated a human neuronal model of HSP-SPG7 using induced pluripotent stem (iPS) cell t...

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Bibliographic Details
Main Authors: Gautam Wali, Yan Li, Erandhi Liyanage, Kishore R. Kumar, Margot L. Day, Carolyn M. Sue
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Neuroscience
Subjects:
hereditary spastic paraplegia (HSP)
mitochondria
induced pluripotent stem (iPS) cell
cortical neurons
high throughput imaging (HTI)
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1231584/full

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https://www.frontiersin.org/articles/10.3389/fnins.2023.1231584/full

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