SorLA Controls Neurotrophic Activity by Sorting of GDNF and Its Receptors GFRα1 and RET

SorLA Controls Neurotrophic Activity by Sorting of GDNF and Its Receptors GFRα1 and RET

Glial cell-line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor that has reached clinical trials for Parkinson’s disease. GDNF binds to its coreceptor GFRα1 and signals through the transmembrane receptor tyrosine kinase RET, or RET independently through NCAM or syndecan-3. Whereas...

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Bibliographic Details
Main Authors: Simon Glerup, Maria Lume, Ditte Olsen, Jens R. Nyengaard, Christian B. Vaegter, Camilla Gustafsen, Erik I. Christensen, Mads Kjolby, Anders Hay-Schmidt, Dirk Bender, Peder Madsen, Mart Saarma, Anders Nykjaer, Claus M. Petersen
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471200455X

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http://www.sciencedirect.com/science/article/pii/S221112471200455X

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