Cell-intrinsic NF-κB activation is critical for the development of natural regulatory T cells in mice.

Cell-intrinsic NF-κB activation is critical for the development of natural regulatory T cells in mice.

BACKGROUND:Naturally occurring CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells develop in the thymus and represent a mature T cell subpopulation critically involved in maintaining peripheral tolerance. The differentiation of Treg cells in the thymus requires T cell receptor (TCR)/CD28 stimulation al...

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Bibliographic Details
Main Authors: Eva Gückel, Silke Frey, Mario M Zaiss, Georg Schett, Sankar Ghosh, Reinhard E Voll
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3097234?pdf=render

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http://europepmc.org/articles/PMC3097234?pdf=render

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