Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation
Riboswitches are non-coding RNA elements that detect metabolites and control expression by regulating mRNA levels or translation. Here, the authors provide evidence that theE. coli thiC riboswitch has a pause site in the translation initiation region that acts as a checkpoint for thiCexpression.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13892 |
| _version_ | 1818851493790351360 |
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| author | Adrien Chauvier Frédéric Picard-Jean Jean-Christophe Berger-Dancause Laurène Bastet Mohammad Reza Naghdi Audrey Dubé Pierre Turcotte Jonathan Perreault Daniel A. Lafontaine |
| author_facet | Adrien Chauvier Frédéric Picard-Jean Jean-Christophe Berger-Dancause Laurène Bastet Mohammad Reza Naghdi Audrey Dubé Pierre Turcotte Jonathan Perreault Daniel A. Lafontaine |
| author_sort | Adrien Chauvier |
| collection | DOAJ |
| description | Riboswitches are non-coding RNA elements that detect metabolites and control expression by regulating mRNA levels or translation. Here, the authors provide evidence that theE. coli thiC riboswitch has a pause site in the translation initiation region that acts as a checkpoint for thiCexpression. |
| first_indexed | 2024-12-19T07:05:54Z |
| format | Article |
| id | doaj.art-57c5865f15864c03ba74e3b730ffa5e6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T07:05:54Z |
| publishDate | 2017-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-57c5865f15864c03ba74e3b730ffa5e62022-12-21T20:31:16ZengNature PortfolioNature Communications2041-17232017-01-018111210.1038/ncomms13892Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulationAdrien Chauvier0Frédéric Picard-Jean1Jean-Christophe Berger-Dancause2Laurène Bastet3Mohammad Reza Naghdi4Audrey Dubé5Pierre Turcotte6Jonathan Perreault7Daniel A. Lafontaine8Department of Biology, Faculty of Science, RNA Group, Université de SherbrookeDepartment of Biology, Faculty of Science, RNA Group, Université de SherbrookeDepartment of Biology, Faculty of Science, RNA Group, Université de SherbrookeDepartment of Biology, Faculty of Science, RNA Group, Université de SherbrookeINRS-Institut Armand-FrappierDepartment of Biology, Faculty of Science, RNA Group, Université de SherbrookeDepartment of Biology, Faculty of Science, RNA Group, Université de SherbrookeINRS-Institut Armand-FrappierDepartment of Biology, Faculty of Science, RNA Group, Université de SherbrookeRiboswitches are non-coding RNA elements that detect metabolites and control expression by regulating mRNA levels or translation. Here, the authors provide evidence that theE. coli thiC riboswitch has a pause site in the translation initiation region that acts as a checkpoint for thiCexpression.https://doi.org/10.1038/ncomms13892 |
| spellingShingle | Adrien Chauvier Frédéric Picard-Jean Jean-Christophe Berger-Dancause Laurène Bastet Mohammad Reza Naghdi Audrey Dubé Pierre Turcotte Jonathan Perreault Daniel A. Lafontaine Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation Nature Communications |
| title | Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation |
| title_full | Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation |
| title_fullStr | Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation |
| title_full_unstemmed | Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation |
| title_short | Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation |
| title_sort | transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation |
| url | https://doi.org/10.1038/ncomms13892 |
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