Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition.

Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition.

Carbonic anhydrases (CAs) have been linked to tumor progression, particularly membrane-bound CA isoform IX (CA IX). The role of CA IX in the context of breast cancer is to regulate the pH of the tumor microenvironment. In contrast to CA IX, expression of CA XII, specifically in breast cancer, is ass...

Full description

Bibliographic Details
Main Authors: Mam Y Mboge, Zhijuan Chen, Alyssa Wolff, John V Mathias, Chingkuang Tu, Kevin D Brown, Murat Bozdag, Fabrizio Carta, Claudiu T Supuran, Robert McKenna, Susan C Frost
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6242694?pdf=render

Internet

http://europepmc.org/articles/PMC6242694?pdf=render

Similar Items