Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

Nonalcoholic steatohepatitis (NASH) is associated with oxidative stress. We surmised that pharmacologic activation of NF-E2 p45-related factor 2 (Nrf2) using the acetylenic tricyclic bis(cyano enone) TBE-31 would suppress NASH because Nrf2 is a transcriptional master regulator of intracellular redox...

Full description

Bibliographic Details
Main Authors: Ritu S. Sharma, David J. Harrison, Dorothy Kisielewski, Diane M. Cassidy, Alison D. McNeilly, Jennifer R. Gallagher, Shaun V. Walsh, Tadashi Honda, Rory J. McCrimmon, Albena T. Dinkova-Kostova, Michael L.J. Ashford, John F. Dillon, John D. Hayes
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
NASH
Nrf2
TBE-31
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X17301807

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X17301807

Similar Items