The Oncoprotein SKI Acts as A Suppressor of NK Cell-Mediated Immunosurveillance in PDAC

The Oncoprotein SKI Acts as A Suppressor of NK Cell-Mediated Immunosurveillance in PDAC

Drugs targeting epigenetic mechanisms such as histone deacetylase inhibitors (HDACi) suppress tumor growth. HDACi also induce the expression of ligands for the cytotoxicity receptor NKG2D rendering tumors more susceptible to natural killer (NK) cell-dependent killing. The major acetylases responsibl...

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Bibliographic Details
Main Authors: Viviane Ponath, Miriam Frech, Mathis Bittermann, Reem Al Khayer, Andreas Neubauer, Cornelia Brendel, Elke Pogge von Strandmann
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
pancreatic tumor
NK cell immunosurveillance
NKG2D
histon (de)acetylation
Online Access:https://www.mdpi.com/2072-6694/12/10/2857

Internet

https://www.mdpi.com/2072-6694/12/10/2857

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