Ligand-independent activation of platelet-derived growth factor receptor β promotes vitreous-induced contraction of retinal pigment epithelial cells

Ligand-independent activation of platelet-derived growth factor receptor β promotes vitreous-induced contraction of retinal pigment epithelial cells

Abstract Background Epiretinal membranes in patients with proliferative vitreoretinopathy (PVR) consist of extracellular matrix and a number of cell types including retinal pigment epithelial (RPE) cells and fibroblasts, whose contraction causes retinal detachment. In RPE cells depletion of platelet...

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Bibliographic Details
Main Authors: Yajian Duan, Wenyi Wu, Jing Cui, Joanne Aiko Matsubara, Andrius Kazlauskas, Gaoen Ma, Xiaorong Li, Hetian Lei
Format: Article
Language:English
Published: BMC 2023-08-01
Series:BMC Ophthalmology
Subjects:
Vitreous
Indirect activation
PDGFRβ
Akt
Retinal pigment epithelial cells
Proliferation
Online Access:https://doi.org/10.1186/s12886-023-03089-8

Internet

https://doi.org/10.1186/s12886-023-03089-8

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