Overexpression of Wild-Type Human Alpha-Synuclein Causes Metabolism Abnormalities in Thy1-aSYN Transgenic Mice

Overexpression of Wild-Type Human Alpha-Synuclein Causes Metabolism Abnormalities in Thy1-aSYN Transgenic Mice

Parkinson’s disease is a progressive neurodegenerative disorder characterized by loss of dopaminergic neurons, pathological accumulation of alpha-synuclein and motor symptoms, but also by non-motor symptoms. Metabolic abnormalities including body weight loss have been reported in patients and could...

Full description

Bibliographic Details
Main Authors: Elodie Cuvelier, Mathieu Méquinion, Coline Leghay, William Sibran, Aliçia Stievenard, Alessia Sarchione, Marie-Amandine Bonte, Christel Vanbesien-Mailliot, Odile Viltart, Kevin Saitoski, Emilie Caron, Alexandra Labarthe, Thomas Comptdaer, Pierre Semaille, Hélène Carrié, Eugénie Mutez, Bernard Gressier, Alain Destée, Marie-Christine Chartier-Harlin, Karim Belarbi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
body weight
energy metabolism
insulin
leptin
mTOR
neurodegeneration
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00321/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00321/full

Similar Items