Actions of a Novel Bacterial Topoisomerase Inhibitor against <i>Neisseria gonorrhoeae</i> Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks

Actions of a Novel Bacterial Topoisomerase Inhibitor against <i>Neisseria gonorrhoeae</i> Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks

Novel bacterial topoisomerase inhibitors (NBTIs) are an emerging class of antibacterials that target gyrase and topoisomerase IV. A hallmark of NBTIs is their ability to induce gyrase/topoisomerase IV-mediated single-stranded DNA breaks and suppress the generation of double-stranded breaks. However,...

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Bibliographic Details
Main Authors: Soziema E. Dauda, Jessica A. Collins, Jo Ann W. Byl, Yanran Lu, Jack C. Yalowich, Mark J. Mitton-Fry, Neil Osheroff
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
novel bacterial topoisomerase inhibitor
NBTI
type II topoisomerase
gyrase
topoisomerase IV
DNA cleavage
Online Access:https://www.mdpi.com/1422-0067/24/15/12107

Internet

https://www.mdpi.com/1422-0067/24/15/12107

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