Transcriptional Response to Standard AML Drugs Identifies Synergistic Combinations

Transcriptional Response to Standard AML Drugs Identifies Synergistic Combinations

Unlike genomic alterations, gene expression profiles have not been widely used to refine cancer therapies. We analyzed transcriptional changes in acute myeloid leukemia (AML) cell lines in response to standard first-line AML drugs cytarabine and daunorubicin by means of RNA sequencing. Those changes...

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Bibliographic Details
Main Authors: Piyush More, Joëlle Aurelie Mekontso Ngaffo, Ute Goedtel-Armbrust, Patricia S. Hähnel, Udo F. Hartwig, Thomas Kindler, Leszek Wojnowski
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
AML
transcription
gene expression changes
cytarabine
daunorubicin
combination therapy
Online Access:https://www.mdpi.com/1422-0067/24/16/12926

Internet

https://www.mdpi.com/1422-0067/24/16/12926

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