Development and evaluation of antibody-capture immunoassays for detection of Lassa virus nucleoprotein-specific immunoglobulin M and G.

Development and evaluation of antibody-capture immunoassays for detection of Lassa virus nucleoprotein-specific immunoglobulin M and G.

The classical method for detection of Lassa virus-specific antibodies is the immunofluorescence assay (IFA) using virus-infected cells as antigen. However, IFA requires laboratories of biosafety level 4 for assay production and an experienced investigator to interpret the fluorescence signals. There...

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Bibliographic Details
Main Authors: Martin Gabriel, Donatus I Adomeh, Jacqueline Ehimuan, Jennifer Oyakhilome, Emmanuel O Omomoh, Yemisi Ighodalo, Thomas Olokor, Kofi Bonney, Meike Pahlmann, Petra Emmerich, Michaela Lelke, Linda Brunotte, Stephan Ölschläger, Corinna Thomé-Bolduan, Beate Becker-Ziaja, Carola Busch, Ikponmwosa Odia, Ephraim Ogbaini-Emovon, Peter O Okokhere, Sylvanus A Okogbenin, George O Akpede, Herbert Schmitz, Danny A Asogun, Stephan Günther
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-03-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5892945?pdf=render

Internet

http://europepmc.org/articles/PMC5892945?pdf=render

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