Early Gβγ-GRK2 Inhibition Ameliorates Osteoarthritis Development by Simultaneous Anti-Inflammatory and Chondroprotective Effects

Early Gβγ-GRK2 Inhibition Ameliorates Osteoarthritis Development by Simultaneous Anti-Inflammatory and Chondroprotective Effects

The G-protein-coupled receptor kinase 2 (GRK2) is an important regulator of inflammation and pathological macrophage phenotype in a variety of diseases. We hypothesize that Gβγ-GRK2 signaling promotes the early inflammatory response and chondrocyte loss in osteoarthritis (OA). Using the destabilizat...

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Bibliographic Details
Main Authors: Vengadeshprabhu Karuppagounder, William Pinamont, Natalie Yoshioka, Reyad Elbarbary, Fadia Kamal
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
osteoarthritis
synovitis
G-protein-coupled receptor kinase 2
therapeutics
Online Access:https://www.mdpi.com/1422-0067/23/14/7933

Internet

https://www.mdpi.com/1422-0067/23/14/7933

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