Inhibitory short peptides targeting EPS8/ABI1/SOS1 tri-complex suppress invasion and metastasis of ovarian cancer cells

Inhibitory short peptides targeting EPS8/ABI1/SOS1 tri-complex suppress invasion and metastasis of ovarian cancer cells

Abstract Background We aimed to develop inhibitory short peptides that can prevent protein interactions of SOS1/EPS8/ABI1 tri-complex, a key component essential for ovarian cancer metastasis. Methods Plasmids containing various regions of HA-tagged ABI1 were co-transfected into ovarian cancer cells...

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Bibliographic Details
Main Authors: Xuechen Yu, Chuan Liang, Yuanzhen Zhang, Wei Zhang, Huijun Chen
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Cancer
Subjects:
Ovarian cancer metastasis
Inhibitory short peptide
ABI1
SOS1
EPS8
Online Access:http://link.springer.com/article/10.1186/s12885-019-6087-1

Internet

http://link.springer.com/article/10.1186/s12885-019-6087-1

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