Improving the Efficacy of Quinolylnitrones for Ischemic Stroke Therapy, QN4 and QN15 as New Neuroprotective Agents after Oxygen–Glucose Deprivation/Reoxygenation-Induced Neuronal Injury

Improving the Efficacy of Quinolylnitrones for Ischemic Stroke Therapy, QN4 and QN15 as New Neuroprotective Agents after Oxygen–Glucose Deprivation/Reoxygenation-Induced Neuronal Injury

In our search for new neuroprotective agents for stroke therapy to improve the pharmacological profile of the compound quinolylnitrone QN23, we have prepared and studied sixteen new, related and easily available quinolylnitrones. As a result, we have identified compounds QN4 and QN15 as promising ca...

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Bibliographic Details
Main Authors: José M. Alonso, Alejandro Escobar-Peso, Israel Fernández, Alberto Alcázar, José Marco-Contelles
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceuticals
Subjects:
brain ischemia
DFT calculations
ischemic stroke
neuroprotection
nitrones
quinolylnitrones
Online Access:https://www.mdpi.com/1424-8247/15/11/1363

Internet

https://www.mdpi.com/1424-8247/15/11/1363

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