A Preliminary Investigation of Embedding In Vitro HepaRG Spheroids into Recombinant Human Collagen Type I for the Promotion of Liver Differentiation

Background: In vitro three-dimensional (3D) hepatic spheroid culture has shown great promise in toxicity testing because it better mimics the cell–cell and cell–matrix interactions found in in vivo conditions than that of the traditional two-dimensional (2D) culture. Despite embedding HepaRG spheroi...

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Bibliographic Details
Main Authors: Fang-Chun Liao, Yang-Kao Wang, Ming-Yang Cheng, Ting-Yuan Tu
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Polymers
Subjects:
Online Access:https://www.mdpi.com/2073-4360/14/9/1923