Pacbio Sequencing of PLC/PRF/5 Cell Line and Clearance of HBV Integration Through CRISPR/Cas-9 System

Pacbio Sequencing of PLC/PRF/5 Cell Line and Clearance of HBV Integration Through CRISPR/Cas-9 System

The integration of HBV DNA is one of the carcinogenic mechanisms of HBV. The clearance of HBV integration in hepatocyte is of great significance to cure chronic HBV infection and thereby prevent the occurrence of HBV-related hepatocellular carcinoma (HCC). However, the low throughput of traditional...

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Bibliographic Details
Main Authors: Chia-Chen Chen, Guiwen Guan, Xuewei Qi, Abudurexiti Abulaiti, Ting Zhang, Jia Liu, Fengmin Lu, Xiangmei Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
HBV integration
PLC/PRF/5
third-generation sequencing
pacbio
HBsAg clearance
CRISPR/Cas9
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.676957/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.676957/full

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