Causality of genetically determined metabolites and metabolic pathways on osteoarthritis: a two-sample mendelian randomization study

Causality of genetically determined metabolites and metabolic pathways on osteoarthritis: a two-sample mendelian randomization study

Abstract Background Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases and is the leading cause of pain and disability in the aged population. However, the underlying biological mechanism has not been fully understood. This study aims to reveal the causal effect of circulation...

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Bibliographic Details
Main Authors: Yifei Gu, Qianmei Jin, Jinquan Hu, Xinwei Wang, Wenchao Yu, Zhanchao Wang, Chen Wang, Yang Liu, Yu Chen, Wen Yuan
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Translational Medicine
Subjects:
Osteoarthritis
Genetically determined metabolites
Mendelian randomization
Arginine
Kynurenine
Online Access:https://doi.org/10.1186/s12967-023-04165-9

Internet

https://doi.org/10.1186/s12967-023-04165-9

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