Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma

Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma

Abstract Background Epigenetic silencing of tumor suppressor genes (TSGs) is a key feature of oncogenesis in hepatocellular carcinoma (HCC). Liver-targeted delivery of CRISPR-activation (CRISPRa) systems makes it possible to exploit chromatin plasticity, by reprogramming transcriptional dysregulatio...

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Bibliographic Details
Main Authors: Agustin Sgro, Joseph Cursons, Charlene Waryah, Eleanor A. Woodward, Momeneh Foroutan, Ruqian Lyu, George C. T. Yeoh, Peter J. Leedman, Pilar Blancafort
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Clinical Epigenetics
Subjects:
CRISPRa
Genome multiplexing
Epigenetic editing toolbox
Tumor suppressor genes
Hepatocellular carcinoma
Epigenetic drugs
Online Access:https://doi.org/10.1186/s13148-023-01482-0

Internet

https://doi.org/10.1186/s13148-023-01482-0

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