Calcium, synaptic plasticity and intrinsic homeostasis in Purkinje neuron models
We recently reproduced the complex electrical activity of a Purkinje cell (PC) with very different combinations of ionic channel maximum conductances, suggesting that a large parameter space is available to homeostatic mechanisms. It has been hypothesized that cytoplasmic calcium concentrations cont...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2008-12-01
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| Series: | Frontiers in Computational Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/neuro.10.008.2008/full |
| _version_ | 1818266026857463808 |
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| author | Pablo Achard Pablo Achard Erik De Schutter Erik De Schutter |
| author_facet | Pablo Achard Pablo Achard Erik De Schutter Erik De Schutter |
| author_sort | Pablo Achard |
| collection | DOAJ |
| description | We recently reproduced the complex electrical activity of a Purkinje cell (PC) with very different combinations of ionic channel maximum conductances, suggesting that a large parameter space is available to homeostatic mechanisms. It has been hypothesized that cytoplasmic calcium concentrations control the homeostatic activity sensors. This raises many questions for PCs since in these neurons calcium plays an important role in the induction of synaptic plasticity. To address this question, we generated 148 new PC models. In these models the somatic membrane voltages are stable, but the somatic calcium dynamics are very variable, in agreement with experimental results. Conversely, the calcium signal in spiny dendrites shows only small variability. We demonstrate that this localized control of calcium conductances preserves the induction of long-term depression for all models. We conclude that calcium is unlikely to be the sole activity-sensor in this cell but that there is a strong relationship between activity homeostasis and synaptic plasticity. |
| first_indexed | 2024-12-12T20:00:10Z |
| format | Article |
| id | doaj.art-57f277c7e4cf448c9070118117f28974 |
| institution | Directory Open Access Journal |
| issn | 1662-5188 |
| language | English |
| last_indexed | 2024-12-12T20:00:10Z |
| publishDate | 2008-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Computational Neuroscience |
| spelling | doaj.art-57f277c7e4cf448c9070118117f289742022-12-22T00:13:47ZengFrontiers Media S.A.Frontiers in Computational Neuroscience1662-51882008-12-01210.3389/neuro.10.008.2008311Calcium, synaptic plasticity and intrinsic homeostasis in Purkinje neuron modelsPablo Achard0Pablo Achard1Erik De Schutter2Erik De Schutter3Marder lab,Volen Center for Complex Systems,Brandeis UniversityUniversity of AntwerpOISTUniversity of AntwerpWe recently reproduced the complex electrical activity of a Purkinje cell (PC) with very different combinations of ionic channel maximum conductances, suggesting that a large parameter space is available to homeostatic mechanisms. It has been hypothesized that cytoplasmic calcium concentrations control the homeostatic activity sensors. This raises many questions for PCs since in these neurons calcium plays an important role in the induction of synaptic plasticity. To address this question, we generated 148 new PC models. In these models the somatic membrane voltages are stable, but the somatic calcium dynamics are very variable, in agreement with experimental results. Conversely, the calcium signal in spiny dendrites shows only small variability. We demonstrate that this localized control of calcium conductances preserves the induction of long-term depression for all models. We conclude that calcium is unlikely to be the sole activity-sensor in this cell but that there is a strong relationship between activity homeostasis and synaptic plasticity.http://journal.frontiersin.org/Journal/10.3389/neuro.10.008.2008/fullCalcium Signalingcomputational modelingPurkinje cellsynaptic plasticityactivity homeostasischannel distribution |
| spellingShingle | Pablo Achard Pablo Achard Erik De Schutter Erik De Schutter Calcium, synaptic plasticity and intrinsic homeostasis in Purkinje neuron models Frontiers in Computational Neuroscience Calcium Signaling computational modeling Purkinje cell synaptic plasticity activity homeostasis channel distribution |
| title | Calcium, synaptic plasticity and intrinsic homeostasis in Purkinje neuron models |
| title_full | Calcium, synaptic plasticity and intrinsic homeostasis in Purkinje neuron models |
| title_fullStr | Calcium, synaptic plasticity and intrinsic homeostasis in Purkinje neuron models |
| title_full_unstemmed | Calcium, synaptic plasticity and intrinsic homeostasis in Purkinje neuron models |
| title_short | Calcium, synaptic plasticity and intrinsic homeostasis in Purkinje neuron models |
| title_sort | calcium synaptic plasticity and intrinsic homeostasis in purkinje neuron models |
| topic | Calcium Signaling computational modeling Purkinje cell synaptic plasticity activity homeostasis channel distribution |
| url | http://journal.frontiersin.org/Journal/10.3389/neuro.10.008.2008/full |
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