Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis

Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis

Abstract Miner1 is a redox‐active 2Fe2S cluster protein. Mutations in Miner1 result in Wolfram Syndrome, a metabolic disease associated with diabetes, blindness, deafness, and a shortened lifespan. Embryonic fibroblasts from Miner1−/− mice displayed ER stress and showed hallmarks of the unfolded pro...

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Bibliographic Details
Main Authors: Sandra E. Wiley, Alexander Y. Andreyev, Ajit S. Divakaruni, Robert Karisch, Guy Perkins, Estelle A. Wall, Peter van der Geer, Yi‐Fan Chen, Ting‐Fen Tsai, Melvin I. Simon, Benjamin G. Neel, Jack E. Dixon, Anne N. Murphy
Format: Article
Language:English
Published: Springer Nature 2013-05-01
Series:EMBO Molecular Medicine
Subjects:
calcium
endoplasmic reticulum
mitochondria
oxidative stress
Wolfram Syndrome
Online Access:https://doi.org/10.1002/emmm.201201429

Internet

https://doi.org/10.1002/emmm.201201429

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