NOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages

NOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages

Abstract Objective Synovial inflammation, which precedes other pathological changes in osteoarthritis (OA), is primarily initiated by activation and M1 polarization of macrophages. While macrophages play a pivotal role in the inflammatory process of OA, the mechanisms underlying their activation and...

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Bibliographic Details
Main Authors: Changchuan Li, Zhuji Ouyang, Yuhsi Huang, Sipeng Lin, Shixun Li, Jing Xu, Taihe Liu, Jionglin Wu, Peidong Guo, Zhong Chen, Haoyu Wu, Yue Ding
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Arthritis Research & Therapy
Subjects:
Synovium
Macrophage
Polarization
NOD2
Online Access:https://doi.org/10.1186/s13075-023-03230-4

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