A novel quinoline derivative, DFIQ, sensitizes NSCLC cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage

A novel quinoline derivative, DFIQ, sensitizes NSCLC cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage

Abstract Background The development of nonapoptotic programmed cell death inducers as anticancer agents has emerged as a cancer therapy field. Ferroptosis, ferrous ion-driven programmed cell death that is induced by redox imbalance and dysfunctional reactive oxygen species (ROS) clearance, is trigge...

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Bibliographic Details
Main Authors: Yung-Ding Bow, Ching-Chung Ko, Wen-Tsan Chang, Sih-Yan Chou, Chun-Tzu Hung, Jau-Ling Huang, Chih-Hua Tseng, Yeh-Long Chen, Ruei-Nian Li, Chien-Chih Chiu
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Cancer Cell International
Subjects:
NSCLC
Ferroptosis
Chemotherapy
Camptothecin derivative
Mitochondrial dysfunction
Autophagic flux disruption
Online Access:https://doi.org/10.1186/s12935-023-02984-w

Internet

https://doi.org/10.1186/s12935-023-02984-w

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