Reversal of mitochondrial permeability transition pore and pancreas degeneration by chloroform fraction of Ocimum gratissimum (L.) leaf extract in type 2 diabetic rat model

Reversal of mitochondrial permeability transition pore and pancreas degeneration by chloroform fraction of Ocimum gratissimum (L.) leaf extract in type 2 diabetic rat model

Introduction: Unmanaged Diabetes Mellitus (DM) usually results to tissue wastage because of mitochondrial dysfunction. Adverse effects of some drugs used in the management of DM necessitates the search for alternative therapy from plant origin with less or no side effects. Ocimum gratissimum (L.) (O...

Full description

Bibliographic Details
Main Authors: A. J. Salemcity, John Oludele Olanlokun, A. O. Olowofolahan, F. O. Olojo, Ayodeji Mathias Adegoke, O. O. Olorunsogo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
Ocimum gratissimum (L.)
mitochondrial permeability transition pore
diabetes mellitus
glucose homeostasis
mitochondrial dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1231826/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1231826/full

Similar Items