An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans

An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans

In the nematode C. elegans, insulin signaling regulates development and aging in response to the secretion of numerous insulin peptides. Here, we describe a novel, non-signaling isoform of the nematode insulin receptor (IR), DAF-2B, that modulates insulin signaling by sequestration of insulin peptid...

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Bibliographic Details
Main Authors: Bryan A Martinez, Pedro Reis Rodrigues, Ricardo M Nuñez Medina, Prosenjit Mondal, Neale J Harrison, Museer A Lone, Amanda Webster, Aditi U Gurkar, Brock Grill, Matthew S Gill
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
dauer formation
alternative splicing
insulin sensitivity
DAF-2
aging
Online Access:https://elifesciences.org/articles/49917

Internet

https://elifesciences.org/articles/49917

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