Overactivation of the IGF signalling pathway in osteosarcoma: a potential therapeutic target?

Abstract Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. More than a third of patients do not respond to standard therapy and urgently require alternative treatment options. Due to a high degree of inter‐ and intra‐tumoural genomic heterogeneity and complex...

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Bibliographic Details
Main Authors: Baptiste Ameline, Michal Kovac, Michaela Nathrath, Maxim Barenboim, Olaf Witt, Andreas H Krieg, Daniel Baumhoer
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:The Journal of Pathology: Clinical Research
Subjects:
Online Access:https://doi.org/10.1002/cjp2.191