Crotoxin Conjugated to SBA-15 Nanostructured Mesoporous Silica Induces Long-Last Analgesic Effect in the Neuropathic Pain Model in Mice

Crotoxin Conjugated to SBA-15 Nanostructured Mesoporous Silica Induces Long-Last Analgesic Effect in the Neuropathic Pain Model in Mice

Neuropathic pain is a disease caused by structural and functional plasticity in central and peripheral sensory pathways that produce alterations in nociceptive processing. Currently, pharmacological treatment for this condition remains a challenge. Crotoxin (CTX), the main neurotoxin of Crotalus dur...

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Bibliographic Details
Main Authors: Morena Brazil Sant’Anna, Flavia Souza Ribeiro Lopes, Louise Faggionato Kimura, Aline Carolina Giardini, Osvaldo Augusto Sant’Anna, Gisele Picolo
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Toxins
Subjects:
neuropathic pain 1
crotoxin 2
sba-15 nanostructured silica 3
partial sciatic nerve ligation 4
analgesia 5
hypernociception 6
Online Access:https://www.mdpi.com/2072-6651/11/12/679

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https://www.mdpi.com/2072-6651/11/12/679

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