Structural Features and Toxicity of α-Synuclein Oligomers Grown in the Presence of DOPAC

Structural Features and Toxicity of α-Synuclein Oligomers Grown in the Presence of DOPAC

The interplay between α-synuclein and dopamine derivatives is associated with oxidative stress-dependent neurodegeneration in Parkinson’s disease (PD). The formation in the dopaminergic neurons of intraneuronal inclusions containing aggregates of α-synuclein is a typical hallmark of PD. Even though...

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Bibliographic Details
Main Authors: Luana Palazzi, Benedetta Fongaro, Manuela Leri, Laura Acquasaliente, Massimo Stefani, Monica Bucciantini, Patrizia Polverino de Laureto
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
α-synuclein aggregation inhibition
fibril inhibition
DOPAC
Parkinson’s disease
protein oligomerization
oligomer toxicity
Online Access:https://www.mdpi.com/1422-0067/22/11/6008

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https://www.mdpi.com/1422-0067/22/11/6008

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