Blood expression profiles of fragile X premutation carriers identify candidate genes involved in neurodegenerative and infertility phenotypes

Blood expression profiles of fragile X premutation carriers identify candidate genes involved in neurodegenerative and infertility phenotypes

Male premutation carriers presenting between 55 and 200 CGG repeats in the Fragile-X-associated (FMR1) gene are at risk of developing Fragile X Tremor/Ataxia Syndrome (FXTAS), and females undergo Premature Ovarian Failure (POF1). Here, we have evaluated gene expression profiles from blood in male FM...

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Bibliographic Details
Main Authors: Elisabet Mateu-Huertas, Laia Rodriguez-Revenga, Maria Isabel Alvarez-Mora, Irene Madrigal, Rob Willemsen, Montserrat Milà, Eulàlia Martí, Xavier Estivill
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Neurobiology of Disease
Subjects:
Fragile X Tremor/Ataxia Syndrome
Fragile X associated Premature Ovarian Insufficiency
Early at menopause 1 (EAP1)
Histone deacetylase 5 (HDAC5)
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000072

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http://www.sciencedirect.com/science/article/pii/S0969996114000072

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