Cancer-Associated Mutations of the Adenosine A<sub>2A</sub> Receptor Have Diverse Influences on Ligand Binding and Receptor Functions

Cancer-Associated Mutations of the Adenosine A<sub>2A</sub> Receptor Have Diverse Influences on Ligand Binding and Receptor Functions

The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>AR) is a class A G-protein-coupled receptor (GPCR). It is an immune checkpoint in the tumor micro-environment and has become an emerging target for cancer treatment. In this study, we aimed to explore the effects of cancer-...

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Bibliographic Details
Main Authors: Chenlin Feng, Xuesong Wang, Willem Jespers, Rongfang Liu, Sofía Denise Zamarbide Losada, Marina Gorostiola González, Gerard J. P. van Westen, Erik H. J. Danen, Laura H. Heitman
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Molecules
Subjects:
adenosine A<sub>2A</sub> receptor
cancer-associated mutation
GPCR
binding affinity
impedance-based cell-morphology assay
structure–activity relationship
Online Access:https://www.mdpi.com/1420-3049/27/15/4676

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https://www.mdpi.com/1420-3049/27/15/4676

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