Reactive Astrocytes Derived From Human Induced Pluripotent Stem Cells Suppress Oligodendrocyte Precursor Cell Differentiation

Reactive Astrocytes Derived From Human Induced Pluripotent Stem Cells Suppress Oligodendrocyte Precursor Cell Differentiation

Astrocytes are instrumental in maintaining central nervous system (CNS) homeostasis and responding to injury. A major limitation of studying neurodegenerative diseases like multiple sclerosis (MS) is lack of human pathological specimens obtained during the acute stages, thereby relegating research t...

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Bibliographic Details
Main Authors: Matthew D. Smith, Xitiz Chamling, Alexander J. Gill, Hector Martinez, Weifeng Li, Kathryn C. Fitzgerald, Elias S. Sotirchos, Dorota Moroziewicz, Lauren Bauer, Daniel Paull, Marjan Gharagozloo, Pavan Bhargava, Donald J. Zack, Valentina Fossati, Peter A. Calabresi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
multiple sclerosis
astrocyte
oligodendrocyte
neurotoxicity
induced pluripotent stem cell (iPSC)
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.874299/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.874299/full

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