Reactive Astrocytes Derived From Human Induced Pluripotent Stem Cells Suppress Oligodendrocyte Precursor Cell Differentiation

Reactive Astrocytes Derived From Human Induced Pluripotent Stem Cells Suppress Oligodendrocyte Precursor Cell Differentiation

Astrocytes are instrumental in maintaining central nervous system (CNS) homeostasis and responding to injury. A major limitation of studying neurodegenerative diseases like multiple sclerosis (MS) is lack of human pathological specimens obtained during the acute stages, thereby relegating research t...

Full description

Bibliographic Details
Main Authors:	Matthew D. Smith, Xitiz Chamling, Alexander J. Gill, Hector Martinez, Weifeng Li, Kathryn C. Fitzgerald, Elias S. Sotirchos, Dorota Moroziewicz, Lauren Bauer, Daniel Paull, Marjan Gharagozloo, Pavan Bhargava, Donald J. Zack, Valentina Fossati, Peter A. Calabresi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-05-01
Series:	Frontiers in Molecular Neuroscience
Subjects:	multiple sclerosis astrocyte oligodendrocyte neurotoxicity induced pluripotent stem cell (iPSC)
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2022.874299/full

Similar Items

A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome
by: K. Ahuja, et al.
Published: (2024-08-01)

Optimization of a human induced pluripotent stem cell-derived sensory neuron model for the in vitro evaluation of taxane-induced neurotoxicity
by: Erica L Cantor, et al.
Published: (2024-08-01)

Neonicotinoid Pesticides Affect Developing Neurons in Experimental Mouse Models and in Human Induced Pluripotent Stem Cell (iPSC)-Derived Neural Cultures and Organoids
by: Alessandro Mariani, et al.
Published: (2024-07-01)

Immune cells and RBCs derived from human induced pluripotent stem cells: method, progress, prospective challenges
by: Jin-he Jiang, et al.
Published: (2024-01-01)

Highly efficient scarless knock-in of reporter genes into human and mouse pluripotent stem cells via transient antibiotic selection.
by: Valentin M Sluch, et al.
Published: (2018-01-01)

Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells
by: Xitiz Chamling, et al.
Published: (2021-01-01)

iPSC-Derived Cardiomyocytes in Inherited Cardiac Arrhythmias: Pathomechanistic Discovery and Drug Development
by: Eline Simons, et al.
Published: (2023-01-01)

Generation of an Alagille syndrome (ALGS) patient-derived induced pluripotent stem cell line (TRNDi032-A) carrying a heterozygous mutation (p.Cys682Leufs*7) in the JAG1 gene
by: Omer Hatim, et al.
Published: (2023-12-01)

Induced pluripotent stem cell-derived brain organoids as potential human model system for chemotherapy induced CNS toxicity
by: Sophie Scholz, et al.
Published: (2022-09-01)

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice
by: Henna Jäntti, et al.
Published: (2022-12-01)

Identity and Maturity of iPSC-Derived Oligodendrocytes in 2D and Organoid Systems
by: Ella Zeldich, et al.
Published: (2024-04-01)

Alzheimer’s in a dish – induced pluripotent stem cell-based disease modeling
by: Sherida de Leeuw, et al.
Published: (2019-07-01)

Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes
by: Francis Grafton, et al.
Published: (2021-08-01)

Choline Ameliorates Disease Phenotypes in Human iPSC Models of Rett Syndrome
by: Chin, Eunice W. M., et al.
Published: (2016)

Induced pluripotent stem cell models of myeloid malignancies and clonal evolution
by: Andreea Reilly, et al.
Published: (2021-04-01)

Harnessing the Power of Induced Pluripotent Stem Cells and Gene Editing Technology: Therapeutic Implications in Hematological Malignancies
by: Ishnoor Sidhu, et al.
Published: (2021-10-01)

A New Induction Method for the Controlled Differentiation of Human-Induced Pluripotent Stem Cells Using Frozen Sections
by: Susumu Tadokoro, et al.
Published: (2021-10-01)

Podocytes derived from human induced pluripotent stem cells: characterization, comparison, and modeling of diabetic kidney disease
by: Julie Bejoy, et al.
Published: (2022-07-01)

Pluripotent Stem Cells for Spinal Cord Injury Repair
by: Maria Martin-Lopez, et al.
Published: (2021-11-01)

Disease Modeling of Mitochondrial Cardiomyopathy Using Patient-Specific Induced Pluripotent Stem Cells
by: Takeshi Tokuyama, et al.
Published: (2021-09-01)

Using human pluripotent stem cell models to study autism in the era of big data
by: Ralda Nehme, et al.
Published: (2020-03-01)

Particulate matter from car exhaust alters function of human iPSC-derived microglia
by: Henna Jäntti, et al.
Published: (2024-02-01)

Expression of Lineage Transcription Factors Identifies Differences in Transition States of Induced Human Oligodendrocyte Differentiation
by: Florian J. Raabe, et al.
Published: (2022-01-01)

Differentiation of Glial Cells From hiPSCs: Potential Applications in Neurological Diseases and Cell Replacement Therapy
by: Wei Zheng, et al.
Published: (2018-08-01)

Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS
by: Ernesto Manzo, et al.
Published: (2019-06-01)

Generation and Characterization of iPS Cells Derived from APECED Patients for Gene Correction
by: Eira Karvonen, et al.
Published: (2022-04-01)

Quantitative Proteomics of Polarised Macrophages Derived from Induced Pluripotent Stem Cells
by: Gavuthami Murugesan, et al.
Published: (2022-01-01)

Ex Vivo Integration of Human Stem Retinal Ganglion Cells into the Mouse Retina
by: Louis-Philippe Croteau, et al.
Published: (2022-10-01)

An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders
by: Marie-France Dorion, et al.
Published: (2024-04-01)

Exosomes From Induced Pluripotent Stem Cell–Derived Cardiomyocytes Promote Autophagy for Myocardial Repair
by: Michelle R. Santoso, et al.
Published: (2020-03-01)

OSCI: standardized stem cell ontology representation and use cases for stem cell investigation
by: Yongqun He, et al.
Published: (2019-04-01)

Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening
by: Chia-Yu Chang, et al.
Published: (2020-04-01)

High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells
by: Weifeng Li, et al.
Published: (2023-03-01)

High-Yield Human Induced Pluripotent Stem Cell-Derived Monocytes and Macrophages Are Functionally Comparable With Primary Cells
by: Di Cui, et al.
Published: (2021-04-01)

In vitro Models for Seizure-Liability Testing Using Induced Pluripotent Stem Cells
by: Alastair I. Grainger, et al.
Published: (2018-08-01)

Extracellular Vesicles from Skeletal Muscle Cells Efficiently Promote Myogenesis in Induced Pluripotent Stem Cells
by: Denisa Baci, et al.
Published: (2020-06-01)

Progress and emerging techniques for biomaterial-based derivation of mesenchymal stem cells (MSCs) from pluripotent stem cells (PSCs)
by: Nityanand Prakash, et al.
Published: (2023-04-01)

Premyelinating Oligodendrocytes: Mechanisms Underlying Cell Survival and Integration
by: Ethan G. Hughes, et al.
Published: (2021-07-01)

Generation of the induced pluripotent stem cell line UKWNLi005-A derived from a patient with the GLA mutation c.376A > G of unknown pathogenicity in Fabry disease
by: Maximilian Breyer, et al.
Published: (2022-05-01)

Investigating nanoplastics toxicity using advanced stem cell-based intestinal and lung in vitro models
by: Mathias Busch, et al.
Published: (2023-01-01)