Synthetic Prostacyclin Agonist Attenuates Pressure-Overloaded Cardiac Fibrosis by Inhibiting FMT

Synthetic Prostacyclin Agonist Attenuates Pressure-Overloaded Cardiac Fibrosis by Inhibiting FMT

Fibroblast-to-myofibroblast transition (FMT) is the primary inducer of cardiac fibrosis. ONO-1301, a synthetic prostacyclin agonist, reportedly promotes tissue fibrosis repair by enhancing anti-fibrotic cytokine production. We hypothesized that ONO-1301 attenuates pressure-overloaded cardiac fibrosi...

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Bibliographic Details
Main Authors: Kenta Masada, Shigeru Miyagawa, Yoshiki Sakai, Akima Harada, Tomomitsu Kanaya, Yoshiki Sawa
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
ONO-1301
prostacyclin
cardiac fibrosis
fibroblast
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012030190X

Internet

http://www.sciencedirect.com/science/article/pii/S232905012030190X

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