Deletion of NKX3.1 via CRISPR/Cas9 Induces Prostatic Intraepithelial Neoplasia in C57BL/6 Mice

Deletion of NKX3.1 via CRISPR/Cas9 Induces Prostatic Intraepithelial Neoplasia in C57BL/6 Mice

Several techniques have been employed for deletion of the NKX3.1 gene, resulting in developmental defects of the prostate, including alterations in ductal branching morphogenesis and prostatic secretions as well as epithelial hyperplasia and dysplasia. To investigate whether the CRISPR/Cas9-mediated...

Full description

Bibliographic Details
Main Authors: Jin Ju Park MS, Ji Eun Kim PhD, Yoon Jeon PhD, Mi Rim Lee MS, Jun Young Choi MS, Bo Ram Song MS, Ji Won Park MS, Mi Ju Kang MS, Hyeon Jun Choi MS, Su Ji Bae MS, Ho Lee PhD, Byeong Cheol Kang PhD, Dae Youn Hwang PhD
Format: Article
Language:English
Published: SAGE Publishing 2020-10-01
Series:Technology in Cancer Research & Treatment
Online Access:https://doi.org/10.1177/1533033820964425

Internet

https://doi.org/10.1177/1533033820964425

Similar Items