The METTL3/MALAT1/PTBP1/USP8/TAK1 axis promotes pyroptosis and M1 polarization of macrophages and contributes to liver fibrosis

The METTL3/MALAT1/PTBP1/USP8/TAK1 axis promotes pyroptosis and M1 polarization of macrophages and contributes to liver fibrosis

Abstract Pro-inflammatory M1 macrophages, via activating hepatic stellate cells, contribute to liver fibrosis. In this study, we examined the mechanism and the significance of a signaling axis, METTL3/MALAT1/PTBP1/USP8/TAK1, in regulating pyroptosis and M1 polarization of hepatic macrophages. Liver...

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Bibliographic Details
Main Authors: Bo Shu, Ying-Xia Zhou, Hao Li, Rui-Zhi Zhang, Chao He, Xin Yang
Format: Article
Language:English
Published: Nature Publishing Group 2021-11-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00756-x

Internet

https://doi.org/10.1038/s41420-021-00756-x

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