Early Lesion of Post-Primary Tuberculosis: Subclinical Driver of Disease and Target for Vaccines and Host-Directed Therapies

The characteristic lesion of primary tuberculosis is the granuloma as is widely studied in human tissues and animal models. Post-primary tuberculosis is different. It develops only in human lungs and begins as a prolonged subclinical obstructive lobular pneumonia that slowly accumulates mycobacteria...

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Bibliographic Details
Main Authors: Robert E. Brown, Robert L. Hunter
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pathogens
Subjects:
Online Access:https://www.mdpi.com/2076-0817/10/12/1572