Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation

Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation

Inflammasomes play a central role in regulating intestinal barrier function and immunity during steady state and disease. Because the discoveries of a passenger mutation and a colitogenic microbiota in the widely used caspase-1-deficient mouse strain have cast doubt on previously identified direct f...

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Bibliographic Details
Main Authors: Adrian J. Błażejewski, Sophie Thiemann, Alexander Schenk, Marina C. Pils, Eric J.C. Gálvez, Urmi Roy, Ulrike Heise, Marcel R. de Zoete, Richard A. Flavell, Till Strowig
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
caspase-1
caspase-11
colitis
inflammasome
microbiota
colon
intestine
DSS
inflammation-induced tumorigenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717307155

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http://www.sciencedirect.com/science/article/pii/S2211124717307155

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