Drosophila strain specific response to cisplatin neurotoxicity
Drosophila melanogaster has recently been developed as a simple, in vivo, genetic model of chemotherapy-induced peripheral neuropathy. Flies treated with the chemotherapy agent cisplatin display both a neurodegenerative phenotype and cell death in rapidly dividing follicles, mimicking the cell speci...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-10-01
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| Series: | Fly |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19336934.2019.1565257 |
| _version_ | 1797678355914424320 |
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| author | Christopher M. Groen Jewel L. Podratz Kevin Treb Anthony J. Windebank |
| author_facet | Christopher M. Groen Jewel L. Podratz Kevin Treb Anthony J. Windebank |
| author_sort | Christopher M. Groen |
| collection | DOAJ |
| description | Drosophila melanogaster has recently been developed as a simple, in vivo, genetic model of chemotherapy-induced peripheral neuropathy. Flies treated with the chemotherapy agent cisplatin display both a neurodegenerative phenotype and cell death in rapidly dividing follicles, mimicking the cell specific responses seen in humans. Cisplatin induces climbing deficiencies and loss of fertility in a dose dependent manner. Drosophila sensitivity to cisplatin in both cell types is affected by genetic background. We show that mutation or RNAi-based knockdown of genes known to be associated with CIPN incidence in humans affect sensitivity of flies to CIPN. Drosophila is a promising model with which to study the effect of genetics on sensitivity to CIPN. |
| first_indexed | 2024-03-11T22:58:32Z |
| format | Article |
| id | doaj.art-580f71c2a27e4b26a3faa9e84a2fd1a8 |
| institution | Directory Open Access Journal |
| issn | 1933-6934 1933-6942 |
| language | English |
| last_indexed | 2024-03-11T22:58:32Z |
| publishDate | 2018-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Fly |
| spelling | doaj.art-580f71c2a27e4b26a3faa9e84a2fd1a82023-09-21T15:09:08ZengTaylor & Francis GroupFly1933-69341933-69422018-10-01123-417418210.1080/19336934.2019.15652571565257Drosophila strain specific response to cisplatin neurotoxicityChristopher M. Groen0Jewel L. Podratz1Kevin Treb2Anthony J. Windebank3Mayo ClinicMayo ClinicUniversity of WisconsinMayo ClinicDrosophila melanogaster has recently been developed as a simple, in vivo, genetic model of chemotherapy-induced peripheral neuropathy. Flies treated with the chemotherapy agent cisplatin display both a neurodegenerative phenotype and cell death in rapidly dividing follicles, mimicking the cell specific responses seen in humans. Cisplatin induces climbing deficiencies and loss of fertility in a dose dependent manner. Drosophila sensitivity to cisplatin in both cell types is affected by genetic background. We show that mutation or RNAi-based knockdown of genes known to be associated with CIPN incidence in humans affect sensitivity of flies to CIPN. Drosophila is a promising model with which to study the effect of genetics on sensitivity to CIPN.http://dx.doi.org/10.1080/19336934.2019.1565257drosophilachemotherapy-induced peripheral neuropathycisplatinneurodegenerationabc transporterglutathione |
| spellingShingle | Christopher M. Groen Jewel L. Podratz Kevin Treb Anthony J. Windebank Drosophila strain specific response to cisplatin neurotoxicity Fly drosophila chemotherapy-induced peripheral neuropathy cisplatin neurodegeneration abc transporter glutathione |
| title | Drosophila strain specific response to cisplatin neurotoxicity |
| title_full | Drosophila strain specific response to cisplatin neurotoxicity |
| title_fullStr | Drosophila strain specific response to cisplatin neurotoxicity |
| title_full_unstemmed | Drosophila strain specific response to cisplatin neurotoxicity |
| title_short | Drosophila strain specific response to cisplatin neurotoxicity |
| title_sort | drosophila strain specific response to cisplatin neurotoxicity |
| topic | drosophila chemotherapy-induced peripheral neuropathy cisplatin neurodegeneration abc transporter glutathione |
| url | http://dx.doi.org/10.1080/19336934.2019.1565257 |
| work_keys_str_mv | AT christophermgroen drosophilastrainspecificresponsetocisplatinneurotoxicity AT jewellpodratz drosophilastrainspecificresponsetocisplatinneurotoxicity AT kevintreb drosophilastrainspecificresponsetocisplatinneurotoxicity AT anthonyjwindebank drosophilastrainspecificresponsetocisplatinneurotoxicity |