Process induced degradation of carbamazepine during hot melt extrusion

Process induced degradation of carbamazepine during hot melt extrusion

The aim of this study was to evaluate hot melt extrudates of carbamazepine (CBZ) for presence of process induced degradation product iminostilbene (IMB) and quantifying using high performance liquid chromatography (HPLC). CBZ was used as model drug. Hot-melt extrusion (HME) was performed to prepare...

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Bibliographic Details
Main Authors: Sarbamangala Bose, Anant Paradkar, Adrian Kelly, Harika Magam
Format: Article
Language:English
Published: University of Huddersfield Press 2023-12-01
Series:British Journal of Pharmacy
Subjects:
carbamazepine
iminostilbene
hot-melt extrusion
hplc
Online Access:https://www.bjpharm.org.uk/article/1392/galley/1025/view/

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