Ppp4r3a deficiency leads to depression-like behaviors in mice by modulating the synthesis of synaptic proteins

Ppp4r3a deficiency leads to depression-like behaviors in mice by modulating the synthesis of synaptic proteins

Chronic stress is one of the main risk factors for the onset of major depressive disorder. Chronic unpredictable mild stress results in reduced expression of synaptic proteins and depression-like behaviors in rodent models. However, the upstream molecule that senses the demand for synaptic proteins...

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Bibliographic Details
Main Authors: Fei Gao, Ai Liu, Xing Qi, Meitian Wang, Xiao Chen, Shijun Wei, Shang Gao, Yueqing Sun, Ping Sun, Xi Li, Wenjie Sun, Jiangxia Li, Qiji Liu
Format: Article
Language:English
Published: The Company of Biologists 2022-06-01
Series:Disease Models & Mechanisms
Subjects:
major depressive disorder
chronic unpredictable mild stress
ppp4r3a
synthesis of synaptic proteins
mtorc1 signaling
Online Access:http://dmm.biologists.org/content/15/6/dmm049374

Internet

http://dmm.biologists.org/content/15/6/dmm049374

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