SARS-CoV-2 spike protein induces a differential monocyte activation that may contribute to age bias in COVID-19 severity

SARS-CoV-2 spike protein induces a differential monocyte activation that may contribute to age bias in COVID-19 severity

Abstract A strong bias related to age is observed in COVID-19 patients with pediatric subjects developing a milder disease than adults. We hypothesized that a specific SARS-CoV-2 effect conjugated with preexisting differences in the immune systems may explain this. Using flow cytometry, we investiga...

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Bibliographic Details
Main Authors: Ines Ait-Belkacem, Celia Cartagena García, Ewa Millet-Wallisky, Nicolas Izquierdo, Marie Loosveld, Isabelle Arnoux, Pierre-Emmanuel Morange, Franck Galland, Nathalie Lambert, Fabrice Malergue, Jean-Marc Busnel
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-25259-2

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https://doi.org/10.1038/s41598-022-25259-2

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