Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance

Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance

Abstract Background Tumors can evolve and adapt to therapeutic pressure by acquiring genetic and epigenetic alterations that may be transient or stable. A precise understanding of how such events contribute to intratumoral heterogeneity, dynamic subpopulations, and overall tumor fitness will require...

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Bibliographic Details
Main Authors: Christine E. Eyler, Hironori Matsunaga, Volker Hovestadt, Samantha J. Vantine, Peter van Galen, Bradley E. Bernstein
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Genome Biology
Subjects:
Therapy resistance
Glioma stem cells
Epigenetic
Genetic
Tumor heterogeneity
Lineage tracing
Online Access:http://link.springer.com/article/10.1186/s13059-020-02085-1

Internet

http://link.springer.com/article/10.1186/s13059-020-02085-1

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