TAF15 regulates the BRD4/GREM1 axis and activates the gremlin-1-NF-κB pathway to promote OA progression

TAF15 regulates the BRD4/GREM1 axis and activates the gremlin-1-NF-κB pathway to promote OA progression

Background: Anterior cruciate ligament (ACL) injury is recognized as a risk factor for osteoarthritis (OA) progression. Herein, the function of TAF15 in ACL injury-induced OA was investigated. Methods: OA cell model and OA mouse model were established by interleukin-1 beta (IL-1β) stimulation and AC...

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Bibliographic Details
Main Authors: Xiufan Du, Ruomei Xin, Xiaoyan Chen, Guangji Wang, Chunhang Huang, Kai Zhou, Shunli Zhang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Regenerative Therapy
Subjects:
Osteoarthritis
Anterior cruciate ligament injury
TAF15
BRD4
The gremlin-1-NF-κB pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320423000640

Internet

http://www.sciencedirect.com/science/article/pii/S2352320423000640

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