Combination of Cellulose Derivatives and Chitosan-Based Polymers to Investigate the Effect of Permeation Enhancers Added to In Situ Nasal Gels for the Controlled Release of Loratadine and Chlorpheniramine

Combination of Cellulose Derivatives and Chitosan-Based Polymers to Investigate the Effect of Permeation Enhancers Added to In Situ Nasal Gels for the Controlled Release of Loratadine and Chlorpheniramine

The purpose of the study is to develop and assess mucoadhesive in situ nasal gel formulations of loratadine and chlorpheniramine maleate to advance the bioavailability of the drug as compared to its conventional dosage forms. The influence of various permeation enhancers, such as EDTA (0.2% <i>...

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Bibliographic Details
Main Authors: Prasanth Viswanadhan Vasantha, Sheri Peedikayil Sherafudeen, Mohamed Rahamathulla, Sam Thomarayil Mathew, Sandhya Murali, Sultan Alshehri, Faiyaz Shakeel, Prawez Alam, Ala Yahya Sirhan, Bhageerathy Anantha Narayana Iyer
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Polymers
Subjects:
loratadine
chlorpheniramine
chitosan
permeation enhancer
steady state flux
enhancement ratio
Online Access:https://www.mdpi.com/2073-4360/15/5/1206

Internet

https://www.mdpi.com/2073-4360/15/5/1206

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